Supervisors: Gabbiani Chiara
Title: Photoactive Platinum Compounds
Abstract: Platinum inactive prodrugs are interesting candidates for anticancer therapy because have less side effects than cisplatin; in fact, the activation takes place only at the tumor site, where they exert their citotoxicity. Among this class of molecules, photoactive Pt(IV) compounds can be activated to generate the toxic Pt(II) form after a redox reaction with a ligand, promoted by light. It seems that the best ligands to do so are azide anions and that the complex should have a LMCT that, after irradiation of visible light, activates the molecule. The photoactivable Pt(IV) compound designed bears a bis(amino)pyridyl ligand (N-N-N) coordinated to the metallic Pt(II) centre. The remaining equatorial position is an acetate and the square planar complex must be oxidized with an halogen to obtain the octahedral complex in which azides substitute halogens after their precipitation with a silver salt, leading to trans-[Pt(N3)2(N-N-N)(OAc)].