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Supervisors: Prof. Marchetti Fabio
Title: Design, Synthesis and Evaluation of the Anticancer Activity of New Transition Metal Complexes
Abstract:
Iron compounds have attracted increasing attention due to the low cost and biocompatibility associated with the metal element.My project is aimed to the design, synthesis, characterization and evaluation of the biological properties of diiron complexes containing a functionalized bridging hydrocarbyl ligand. In particular, the complexes will be tested as possible CO-releasing agents and also their cytotoxicity will be ascertained towards different cancer cell lines.
Oral communications at congress:
“Synthesis and antiproliferative activity of new ruthenium and osmium complexes with ethacrynic acid derived ligands”. G. Agonigi, P. J. Dyson, M. A. Esteruelas, F. Marchetti, G. Pampaloni, S. Zacchini, XII PhD-Chem Day, CIRCC meeting, Bari, 27-28 March 2015
Poster communications at congress:
“Synthesis and Cytotoxic Activity of Ruthenium Complexes with Ethacrynic Acid Derived Ligands”. G. Agonigi, L. Biancalana, P. J. Dyson, F. Marchetti, G. Pampaloni, E. Păunescu, T. Riedel, S. Zacchini, Euchems 2015, Wrocław.
“Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic Acid-Modified Pyridine- and Triphenylphosphine-Ligands”. G. Agonigi, L. Biancalana, P. J. Dyson, F. Marchetti, G. Pampaloni, E. Păunescu, T. Riedel, S. Zacchini, XXI EuCOMCS, 2015, Bratislava.
Journal articles:
“Synthesis of diiron µ-allenyl complexes by electrophilic addition to propen-2-yl-dimetallacyclopentenone species: A joint experimental and DFT study”, G. Agonigi, M. Bortoluzzi, T. Funaioli, F. Marchetti, G. Pampaloni, S. Zacchini, J. Organomet. Chem., 2013, 731, 61-66.
“Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic Acid-Modified Pyridine- and Triphenylphosphine-Ligands”, G. Agonigi, T. Riedel, S. Zacchini, E. Păunescu, G. Pampaloni, N. Bartalucci, P. J. Dyson, F. Marchetti, Inorg. Chem., 2015, 54, 6504–6512.