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Supervisors: Dr. Fabio di Francesco
Title: Development of novel sensors for quantitative analysis of wound tissue.
Abstract: One obstacle in the treatment of chronic wound patients is the lack of reliable quantification of the status of wound tissue. Hence the choice of the best suited medical treatment is difficult and innovative new sensor technologies are needed in the public health sector. Matrix metalloproteinases (MMPs) are a group of Zinc containing enzymes that catalyze the hydrolysis of damaged tissue, but also attack healthy tissue if over expressed, as in chronic wounds. Consequently, it is desirable to investigate a possible methodology for their detection and monitoring. Herein I intend to design molecular probes which show a change in optical or electrical properties during binding interaction. With enzyme inhibitors as design blueprint this project involves the synthesis of the probes, their attachment to a transducer system as well as the electronic readout and interpretation with the far goal of the invention of a wearable and disposable sensor system for the application on a patient.
Journal articles:
- P. Gross, A. Kirchhain, H. A. Höppe, The Borosulfates K4[BS4O15(OH)], Ba[B2S3O13], and Gd2[B2S6O24], Angew. Chem. Int. Ed. 2016, 55, 4353-4355; Angew. Chem. 2016, 128, 4426-4428.
- Kirchhain, A.; Yu, W.; Engman, L. Organochalcogen stabilizers efficiently protect model polyolefins exposed to chlorinated media, Polymer Degradation and Stability 2015, 118, 82-87.
Poster communications at congresses/schools:
- “Impedometric enzyme quantification via Inhibitor- Enzyme capture for continuos wound monitoring” Poster + Flash communication. Winter School on Physical Organic Chemistry 2017, Bressanone, Italia.