Venerdì 6 giugno 2025 - Ore 10:45 - Aula 22
Prof.ssa Inês Catarina Batista Martins
Department of Pharmacy, University of Copenhagen
  Seminario  

Amorphous forms are ideal candidates to improve the solubility and thus potentially the oral bioavailability of poorly water-soluble drugs. When searching for amorphous forms, only one “amorphous state” is currently considered as a result from the screening process via different preparation methods. However, depending on the preparation conditions, distinctly different amorphous forms with distinct molecular-level organizations as well as physicochemical properties can be isolated and even interconverted between each other in a phenomenon termed polyAmorphism. The occurrence of diversity among amorphous forms of the same drug is therefore a topic of great interest, not only in the investigation of oral drug formulations, but also in the development of amorphous engineering approaches. In this presentation, we will explore the existence of diversity (particularly polyAmorphism) in the amorphous forms of drugs, and discuss how their structural and physicochemical properties are greatly affected by the preparation methods used.