Lunedì 24 giugno 2024 - Ore 14:30 - Aula 22
Prof. Krzysztof Kuciński
Faculty of Chemistry, Adam Mickiewicz University, Poznan (Poland)
  Seminario  

One major focus over the past 15 years has been shifting from expensive noble metal catalysts to more affordable alternatives, such as coordinating 3d metals and main-group catalysis. Thorough process optimization has even allowed for the complete elimination of catalysts, especially in the synthesis of organoboron compounds. Silylation of organic and organometalloidal compounds provides a strategic method for producing valuable siloxanes and silyl-protected intermediates, including silyl ethers and 1-alkynylsilanes. While derivatives with acidic protons, like alcohols, phenols, and silanols, can be readily silylated, halosilanes are typically used for this purpose. However, these reagents present high moisture sensitivity, requiring stoichiometric base and the formation of corrosive byproducts, sparking interest in more sustainable alternatives. Furthermore, using halosilanes can result in chemoselectivity issues, particularly in synthesizing unsymmetrical siloxanes. In response, we have recently developed a range of methods based on dehydrogenative and dealkynative coupling using 3d metal-catalysis or main-group compounds. These methods enable the direct synthesis of Si-X (O, N, C) bonds. Applications in organoboron and organosulfur compounds will also be discussed.