To address these challenges, we propose combining sensor design with chromatographyspectrometry readout, facilitating multicomponent analysis. We designed matrix-compatible, high-capacity probes with flexible shapes and morphologies for LCMS. These probes feature a thin coating of extraction phase with sorbent particles and a binder that forms a protective layer, enabling selective, non-exhaustive sampling of small molecules without affecting the sample matrix. This flexible Solid Phase MicroExtraction (SPME) approach shows superior performance over traditional methods and offers better sustainability by reducing organic solvent use. While the non-exhaustive nature of SPME has faced resistance from regulatory agencies, its green advantages and wide applicability make it a promising tool, especially in areas where alternatives are lacking. Several high-throughput and on-site SPME designs will be highlighted.
Chemical Biopsy SPME Probe, a Green Sample Preparation Tool
Venerdì 20 settembre 2024 - Ore 11:30 - Aula 20
Prof. Janusz Pawliszyn, University of Waterloo
Seminario
Development of devices for chemical determination in complex matrices follows two paths sensor design and hyphenated separation with technologies like GCMS and LCMS. Sensors are portable and simple but typically limited to single component analysis, while separation technologies allow multicomponent determination but are constrained by sample preparation.
