Order and disorder in pharmaceutical solids

Venerdì 6 giugno 2025 - Ore 10:00 - Aula 22
Prof. Thomas Rades
Department of Pharmacy, University of Copenhagen
  Seminario  

Most drug delivery today utilizes solid dosage forms, especially for small molecules. However, the solid state of drugs can take many forms, and increasingly high energy solids are used, with different degrees of disorder, ranging from stable to metastable crystalline forms, to supercooled liquid crystalline forms, to amorphous forms. In this presentation we will initially discuss different solid-state forms and explore their usefulness for drug delivery and then aim to elucidate a better understanding of amorphous forms of the drug molecules themselves, both as a rational basis for the development of ASDs as well as for the exciting opportunity to enable the development of amorphous engineering approaches.